Implement MSDP client deduplication gradually
If you configure clients to deduplicate their own data, do not enable all of those clients at the same time. Implement client deduplication gradually, as follows:
Use the storage server for the initial backup of the clients.
Enable deduplication on only a few clients at a time.
Doing so provides information about deduplication affects the clients other jobs. It also may be easier to evaluate how your environment handles traffic and easier to troubleshoot any problems
If a client cannot tolerate the deduplication processing workload, be prepared to move the deduplication processing back to the storage server.