When you configure remote replication for the first time, start with one replica per appliance. Then monitor the replication performance. Based on the results, you can consider creating additional replicas.

Use a dedicated network for replication.

If you configure remote replication on a 52xx appliance without storage shelves, use that appliance for primary server instances only. If you want to add media and WORM instances, add storage shelves with enough storage capacity to handle them.

Configure email alerts to make sure that you are notified of any issues with the replication.